Lady Gaga tears it up to open the show with a ton of costume changes worthy of "Applause."

Miley Cyrus performs her hit single "We Can't Stop" with huge teddy bears onstage. Begins a medley with Robin Thicke, Kendrick Lamar and 2 Chainz.

Kanye West performs "Blood On The Leaves" live at the 2013 Video Music Awards.

Justin Timberlake performs a medley of his hits: "Take Back The Night," "SexyBack," "Love You Like I Love You," "My Love," etc.

The most iconic boy band of all time, *NSYNC, reunited with ex-front man Justin Timberlake during his epic medley performance. It. Was. Awesome.

Macklemore & Ryan Lewis perform "Same Love" live.

Drake performs a medley of his hit songs live.

Bruno Mars performs his song "Gorilla" live.

Katy Perry performs her song "Roar" for the first time ever live.